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The Underhill Lab aims to understand the processes that govern tissue development, regeneration, and disease. Our particular focus is on elucidating the role of cellular microenvironments in stem cell differentiation and identifying how alterations in microenvironments signals contribute to cancer as well as congenital and degenerative diseases.

Our interdisciplinary efforts span the boundaries of microfabrication, biomaterials, cell and developmental biology, and genomics. Our overall goal is to develop novel cell-based therapeutic approaches for tissue engineering and regenerative medicine.