2024
H. Ryoo, R. Giovanni, H. Kimmel, I. Jain, GH Underhill. Combinatorial microgels for 3D ECM screening and heterogeneous microenvironmental culture of primary human hepatic stellate cells. Advanced Science. 2024.10.1002/advs.202303128
SG Zambuto, I. Jain, HS Theriault, GH Underhill, BAC Harley. Cell chirality of micropatterned endometrial microvascular endothelial cells. Advanced Healthcare Materials. 2024. 10.1002/adhm.202303928
2023
H. Ryoo, H. Kimmel, E. Rondo, GH Underhill. Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications. Bioengineering & Translational Medicine. https://doi.org/10.1002/btm2.10627
I. Jain, A. Brougham-Cook, GH Underhill. Effect of distinct ECM microenvironments on the genome-wide chromatin accessibility and gene expression responses of hepatic stellate cells. Acta Biomaterialia. 2023. https://doi.org/10.1016/j.actbio.2023.06.018
H. Ryoo, GH Underhill. Spatially Defined Cell-Secreted Protein Detection Using Granular Hydrogels: μGeLISA. ACS Biomaterials Science & Engineering. 2023. https://doi.org/10.1021/acsbiomaterials.2c01308
2022
A Brougham-Cook, HRC Kimmel, CP Monckton, D Owen, SR Khetani, GH Underhill. Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses. APL Bioengineering. 2022. https://doi.org/10.1063/5.0097602
CP Monckton, A Brougham-Cook, GH Underhill, SR Khetani. Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays. Acta Biomaterialia. 2022. https://doi.org/10.1016/j.actbio.2022.09.013
I Jain, IC Berg, A Acharya, M Blaauw, N Gosstola, P Perez-Pinera, GH Underhill. Delineating cooperative effects of Notch and biomechanical signals on patterned liver differentiation. Commun Biol. 2022. https://doi.org/10.1038/s42003-022-03840-9
SG Zambuto, I Jain, KBH Clancy, GH Underhill, BAC Harley. Role of Extracellular Matrix Biomolecules on Endometrial Epithelial Cell Attachment and Cytokeratin 18 Expression on Gelatin Hydrogels. ACS Biomaterials Science & Engineering. 2022. https://doi.org/10.1021/acsbiomaterials.2c00247
ST Berent, I Jain, GH Underhill, AM Wagoner Johnson. Simulated Confluence on Micropatterned Substrates Correlates Responses Regulating Cellular Differentiation. Biotechnology and Bioengineering. 2022. https://doi.org/10.1002/bit.28069
2021
A Brougham-Cook, I Jain, DA Kukla, F Masood, H Kimmel, H Ryoo, SR Khetani, GH Underhill. High Throughput Interrogation of Human Liver Stellate Cells Reveal Microenvironmental Regulation of Phenotype. Acta Biomaterialia. 2021. https://doi.org/10.1016/j.actbio.2021.11.015
CP Monckton, A Brougham-Cook, KB Kaylan, GH Underhill, SR Khetani. Elucidating Extracellular Matrix and Stiffness Control of Primary Human Hepatocyte Phenotype via Cell Microarrays. Advanced Materials Interfaces. 2021. https://doi.org/10.1002/admi.202101284
IC Berg, E Mohagheghian, K Habing, N Wang, GH Underhill. Microtissue Geometry and Cell-Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D. Advanced Healthcare Materials. Advanced Healthcare Materials. 2021. https://doi.org/10.1002/adhm.202100223
2020
SD Gentile, AP Kourouklis, H Ryoo, GH Underhill. Integration of Hydrogel Microparticles With Three-Dimensional Liver Progenitor Cell Spheroids. Frontiers in Bioengineering and Biotechnology. 2020. https://doi.org/10.3389/fbioe.2020.00792
2019
GH Underhill, SR Khetani. Emerging trends in modeling human liver disease in vitro. APL Bioengineering. 2019. https://doi.org/10.1063/1.5119090
IC Berg, GH Underhill. High Throughput Traction Force Microscopy for Multicellular Islands on Combinatorial Microarrays. Bio-protocol. 2019. DOI: bio-protocol.org/e3418
2018
KB Kaylan, IC Berg, MJ Biehl, A Brougham-Cook, I Jain, SM Jamil, LH Sargeant, NJ Cornell, LT Raetzman, GH Underhill. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. Elife. 2018. https://doi.org/10.7554/eLife.38536
GH Underhill, SR Khetani. Advances in Engineered Human Liver Platforms for Drug Metabolism Studies. Drug Metabolism and Disposition. DOI: https://doi.org/10.1124/dmd.118.083295
MJ Biehl, KB Kaylan, RJ Thompson, RV Gonzalez, KE Weis, GH Underhill, LT Raetzman. Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling. Developmental Biology. 2018. https://doi.org/10.1016/j.ydbio.2018.06.005
SD Gentile, ME Griebel, EW Anderson, GH Underhill. Click Chemistry-Based DNA Labeling of Cells for Barcoding Applications. Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.8b00435
M Gapinske, N Tague, J Winter, GH Underhill, P Perez-Pinera. Targeted Gene Knock Out Using Nuclease-Assisted Vector Integration: Hemi- and Homozygous Deletion of JAG1. Synthetic Biology. 2018. https://doi.org/10.1007/978-1-4939-7795-6_13
GH Underhill, SR Khetani. Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies. Cellular and Molecular Gastroenterology and Hepatology. 2018. https://doi.org/10.1016/j.jcmgh.2017.11.012
2017
RCA Eguiluz, KB Kaylan, GH Underhill, DE Leckband. Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. Biomaterials. 2017. https://doi.org/10.1016/j.biomaterials.2017.06.010
KB Kaylan, AP Kourouklis, GH Underhill. A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces. JoVE. 2017. DOI: 10.3791/55362
2016
KB Kaylan, SD Gentile, LE Milling, KN Bhinge, F Kosari, GH Underhill. Mapping lung tumor cell drug responses as a function of matrix context and genotype using cell microarrays. Integrative Biology. 2016. https://doi.org/10.1039/c6ib00179c
AP Kourouklis, KB Kaylan, GH Underhill. Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells. Biomaterials. 2016. https://doi.org/10.1016/j.biomaterials.2016.05.016
DFB Malta, NE Reticker-Flynn, CL Da Silva, JMS Cabral, HE Fleming, KS Zaret, SN Bhatia, GH Underhill. Extracellular matrix microarrays to study inductive signaling for endoderm specification. Acta Biomaterialia. 2016. https://doi.org/10.1016/j.actbio.2016.02.014
KB Kaylan, V Ermilova, RC Yada, GH Underhill. Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGFβ and extracellular matrix. Sci Rep 6, 23490. 2016. https://doi.org/10.1038/srep23490