Welcome to the Tissue Development and Engineering Laboratory directed by Dr. Gregory Underhill. Research in the Underhill lab is aimed at understanding the processes that govern tissue development, regeneration, and disease. Our particular focus is on elucidating the role of cellular microenvironments in stem cell differentiation, and identifying how alterations in microenvironmental signals contribute to cancer as well as congenital and degenerative diseases.
Our interdisciplinary efforts span the boundaries of microfabrication, biomaterials, cell and developmental biology, and genomics. Our overall goal is to develop novel cell-based therapeutic approaches for tissue engineering and regenerative medicine.
Congrats to Kerim Kaylan for successfully defending his PhD thesis! First Underhill Lab PhD!
Dr. Underhill gave a talk at the Rare Disease Day Symposium, focused on Alagille Syndrome (Sanford Children's Health Research Center, San Diego).
Our paper investigating the effects of ECM on tumor cell drug responses has been accepted for publication in Integrative Biology. Congrats to Kerim, Stefan, Lauren, and our collaborators at Mayo!