Welcome to the Tissue Development and Engineering Laboratory directed by Dr. Gregory Underhill. Research in the Underhill lab is aimed at understanding the processes that govern tissue development, regeneration, and disease. Our particular focus is on elucidating the role of cellular microenvironments in stem cell differentiation, and identifying how alterations in microenvironmental signals contribute to cancer as well as congenital and degenerative diseases.

Our interdisciplinary efforts span the boundaries of microfabrication, biomaterials, cell and developmental biology, and genomics. Our overall goal is to develop novel cell-based therapeutic approaches for tissue engineering and regenerative medicine.



February 24, 2017

Dr. Underhill gave a talk at the Rare Disease Day Symposium, focused on Alagille Syndrome (Sanford Children's Health Research Center, San Diego).

October 17, 2016

Our paper investigating the effects of ECM on tumor cell drug responses has been accepted for publication in Integrative Biology. Congrats to Kerim, Stefan, Lauren, and our collaborators at Mayo!

October 6-7, 2016

Lab members Kerim, Stefan, and Andreas gave oral presentations at the BMES 2016 Annual Meeting (Minneapolis). Great job!

September 1, 2016

Underhill lab has received an R03 grant from the National Institutes of Health (NIBIB).

July 25, 2016

The lab has been awarded a grant from the National Science Foundation: Biomechanics & Mechanobiology Program (CMMI).